Day 34-36 Chemotherapy

I’m on day 6 of phase 2 chemo which is also day 36 of my treatment. I’m due to have another intrathecal injection today which, having just got over the headache from last time, I’m not looking forward to.  I am, however now unplugged from the pumps and therefore feel a familiar sense of relief.

Day 34 & 35 treatment

The treatment for these past 2 days has followed the same course, frustratingly, due to the length of the courses (and that for some inexplicable reason, they can’t start till midday) they have been running through the night. This means 2 things:

  1. Not much sleep (lots of interruptions)
  2. Regular toilet breaks (due to the volume of fluid absorbed)

The chemicals for both days were as follows:

etoposide – 120mg in 500ml of fluid across a 1 hour course

ifosfamide (+Mesna) – 2900 (+800)mg in 1000ml over 1 hour

Mesna – 2400mg in 1000ml over 12 hours

Day 36 treatment

then finally today I’ll have Methotrexate applied intrathecally (into my spinal fluid) – as far as I’m aware, that’s it for a few days.

My neutrophils will start to drop over the next couple of days (neutropenia is usually expected between day 7-10) and to counteract this, I’ll be given injections of a drug called lenograstim which helps to stimulate the bone marrow (where blood cells are made)

I’m also being give another injection each day which helps to thin the blood and prevent blood clots. It’s supposed to go into my stomach, but it hurts when they put it there so I’ve been asking the nurses to administer into my arm (apparently into the subcutaneous tissue under my skin).

How do I feel?

honestly, I’ve had worse hangovers but I feel fairly grotty. A little disorientated and my brain is feeling lazy- I can’t beat my ipad at chess any more! I sometimes get the feeling of sickness but it goes; I think the anti sickness drugs are working.

Green maple leaf
Green maple leaf

If I get up in the night I get quite dizzy and my blood is taking its time to get back into my brain. I nearly fainted the other night and have therefore have been classed as a falling risk hence the award of green maple leaf. I have been advised to sit on the edge of the bed for a few minutes before getting up, this seems to help although doesn’t half make me feel like an old man.

liz said it’s good practice- thinning hair, unsteady balance, aching joints, unreliable bowels… Can’t wait to be young again!

Day 30 to 33 chemotherapy

Having completed round 1 the ‘R-CODOX-M’ part, I think I was lulled into a false sense of security thinking that the ‘R-IVAC’ cycle would comprise fewer chemicals. It seems that although infused over a shorter period of time, there is a greater volume of therapy.

Day 30 last day home

On Wednesday, I spent the day chilling out and sorting out my things ready to take to the hospital. In the usual convenient manner, having been told to call the ward at 14:00 to confirm arrival time on Thursday, they told me to get into Worcester by 16:00 which didn’t give me much time to arrange a lift and prepare myself for the journey.

on arrival, I went through the usual checking in procedure; general questions, next of kin, any power of attorney, weight, height, blood test, OBS, wrist band, MRSA swab, and logging of belongings. I was then allowed home for the evening although needed to be back in by 8.

Day 31 Chemotherapy

The journey in triggered my headache, so returning to my bed I spent the first part of the morning asleep or resting through the coughs beeps and whirrings of my new room mates.

The chemo started again at 12:00

Cytarabine 3900mg over 3 hours, followed by

Etoposide 120mg over 1 hour

ifosfamide (with Mesna) 2900 (+800)mg over 1 hour

mesna 2400mg over 12 hours

Cytarabine 3900mg over 3 hours

As you can see, this meant that my sleep was interrupted by fluid changes as well as (due to the volume of saline included with the above: 4500ml) regular toilet breaks. This meant that the following morning I was fairly tired.

Day 32 Chemotherapy

The onslaught continued and I spent most of my waking hours trying to sleep:

Cytarabine 3900mg over 6 hours

Etoposide 120mg over 1 hour

Rituximab 375mg over 3 hours

ifosfamide (with Mesna) 2900 (+800)mg over 1 hour

Mesna 2400mg over 12 hours

Cytarabine 3900mg over 3 hours

Day 33 Chemotherapy

I’ve had a few hours break this morning which was a quite a relief from being plugged into the pump.

The therapy is due to start after lunch as follows:

Etoposide 120mg over 1 hour

ifosfamide (with mesna) 2900 (+800)mg over 1 hour

Mesna 2400mg over 12 hours

How do I feel?

My main symptom is lethargy. This could be due to interrupted sleep although I expect some of the way I feel is due to the chemicals floating round my body. My headache has started to ease and although it still persists along with stiff neck and shoulders, it is much more manageable now.

In addition to the standard side effects which seem to coincide with all of the chemotherapy drugs (bruising/bleeding, anemia, sickness, diarrhoea, sore mouth, hair loss) the current round of treatment has  the additional symptoms of eye problems, skin changes, numb hands and feet.

To minimise risk of eye problems, I’m taking medicated eye drops which are applied every 3 hours.

the fact sheet for Mesna under ‘why is Mesna given’ states the following: “if you are given ifosfamide or cyclophosphamide chemotherapy, you may get bleeding in your urine. Both drugs can cause irritation of the bladder lining. Mesna helps prevent this by protecting the lining.” Thankfully, the Mesna seems to have done its job!

my skin has become very dry especially on my hands and face.

I’m also experiencing numb hands and feet, but otherwise, my symptoms are so far mild.

With regard to hair loss, this has slowed down somewhat but I have noticed that my beard hair has been coming out in the shower. In fact I  think I prefer wiping my beard off to shaving so I think I’ll not bother shaving for now!